Innovations in Gene Editing Technology

Request Number N883828
Need details

CRISPR-Cas9 is a widely used technology for the editing of genetic sequences. Thermo Fisher Scientific seeks approaches or technologies to improve the effectiveness of this powerful tool.



Thermo Fisher Scientific is seeking partners and opportunities to develop and commercialize improvements to existing genome editing technology and workflows. CRISPR-Cas9 has emerged as an easy-to-use technology and has quickly become the standard for genome editing, but it has some acknowledged limitations. We are therefore seeking new improvements to the Cas9 system that:


  • Provide higher specificity to reduce off-target effects
  • Show a substantially higher efficiency
  • Reduce or eliminate unwanted mutations


Key Success Criteria

The successful technology improvement should increase the efficiency and/or reduce the off-target effects of the system. Additionally, the successful technology should be backed by performance–benchmarking data against currently available methods in mammalian cells, utilizing commercially available reagents from market-leading companies including

Thermo Fisher Scientific. 


Possible Approaches
  • Engineered Cas9 or related proteins
  • Improved delivery methods
  • Improved guides


Approaches not of interest



Preferred Collaboration types
  • Joint Development
  • Technology Licensing
Items to be submitted
We are looking for concise, nonconfidential proposals. The proposal should:
  • Describe the technical approach
  • Include a description of the responding organization or team and their experience
We recommend:
  • Including a concise abstract summarizing your submission
  • Attaching your proposal
  • Attaching any additional documents

Please note that only nonconfidential information can be accepted. By submitting a response, you confirm that the response does not contain any confidential information.


Point of Contact
Jonathan Jakischa
Area of Interest
  • Medical Products & Services
  • Other
  • Pharmaceuticals
  • Pharmaceutical R & D
  • Other
  • Research Organizations
  • National Laboratories
  • Research Foundations
  • Universities & Colleges
Thermo Fisher Scientific
Due Date
March 30, 2018
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