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Novel Labels and Dyes for Antibodies

Request Number N583625
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Description

Thermo Fisher Scientific is seeking partners and opportunities to further develop and commercialize technologies for enhanced signal detection with antibodies. This includes technologies that provide greater sensitivity and stability over current dyes, labels (i.e. enyzmes), and chemistries. Candidates are desired for use in Western blotting, immunofluorescence on cells and tissues and flow cytometry.

 

Background

 

 

Dyes and antibody labels are extremely important tools to help visualize and quantify protein abundance in complex samples. The development of new dyes over the past 10–20 years, including our InvitrogenTM Alexa FluorTM dyes, has made a big impact on the scientific community expanding the utility and capacity of antibodies to be used in a wide variety of applications. Thermo Fisher Scientific continues to innovate in this space and can partner to work with our scientific teams to incorporate new, better-performing dyes. We are also very interested in new conjugation chemistries that enable more efficient, scalable methods to conjugate dyes and labels to antibodies. There is also great interest in conjugation chemistries that enable enhanced signals.

 

 

Key Success Criteria

The technologies ideally will display the following properties:

  • Be reproducible and scalable
  • Be cost effective at small quantities
  • Be simple and straightforward to use and apply to all antibody types
  • Be free and clear of competing intellectual properties
  • Preferably be patentable
  • Have proof-of-concept already established by benchmarking against competing technologies

 

Possible Approaches
  • New dye molecules
  • New dye scaffolds or multimeric dyes
  • Dyes with better stability and less bleaching
  • Dyes that resist quenching
  • Enzymes that are more stable or higher fidelity
  • Enzymes that are smaller and enable easier conjugate or the ability to add more molecules per antibody
  • Chemistries that are simplified, highly efficient, and site specific
  • Chemistries that add scaffolds to dye–antibody or enzyme–antibody complexes

 

Approaches not of interest

None.

 

Preferred Collaboration types
  • To Be Negotiated
Items to be submitted
We are looking for concise, nonconfidential proposals. The proposal should:
  • Describe the technical approach
  • Include a description of the responding organization or team and their experience
We recommend:
  • Including a concise abstract summarizing your submission
  • Attaching your proposal
  • Attaching any additional documents

Please note that only nonconfidential information can be accepted. By submitting a response, you confirm that the response does not contain any confidential information.

 

Point of Contact
Jonathan Jakischa
Area of Interest
  • Medical Products & Services
  • Other
  • Pharmaceuticals
  • Pharmaceutical R & D
Organization
Thermo Fisher Scientific
Due Date
March 30, 2018
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