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Novel NGS Library Prep Technology

Request Number N183465
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Description

Thermo Fisher Scientific seeks innovative approaches for nucleic acid library preparation. The goal is to facilitate next-generation (high-throughput) sequencing.

 

Background

Thermo Fisher Scientific is seeking partners and opportunities to develop and commercialize nucleic acid library preparation for next-generation sequencing (NGS.) The improvements we seek may relate to a specific type of NGS library preparation or more generally applicable. Ideally, the improvement(s) would surpass performance of existing, market-leading methods from commercial suppliers and include:

 

  • Higher fidelity replication or reverse transcription of target nucleic acid
  • More uniform coverage of either the whole genome or the targeted regions
  • Minimal amplification bias for quantitative applications
  • Ability to index molecules and/or samples
  • Reduced number of steps and simplified procedures
  • Support for low input amounts
  • Amenable to automation on standard liquid-handling platforms

 

Key Success Criteria

The successful technology improvement should meet at least several of the performance metrics as demonstrated by performance benchmarking data against currently available kits from

market-leading companies. The key metrics include:

 

  • Error rate
  • Coverage uniformity
  • Quantitative accuracy
  • Number of steps
  • Amount of input material
  • Sample and cell-type support
  • Minimal reliance on specialized instruments for fragmentation and size selection

 

Possible Approaches

The applications for NGS are very broad and therefore it is recognized that library preparation approaches may vary substantially from current techniques depending on the application.

Approaches that are novel with strong intellectual property (IP) protection will receive preferential consideration.

 

Approaches not of interest

None.

 

Preferred Collaboration types
  • Contract Research
  • Contract Analysis and Testing
  • Technology Licensing
  • Supply Agreement
Items to be submitted
We are looking for concise, nonconfidential proposals. The proposal should:
  • Describe the technical approach
  • Include a description of the responding organization or team and their experience
We recommend:
  • Including a concise abstract summarizing your submission
  • Attaching your proposal
  • Attaching any additional documents

Please note that only nonconfidential information can be accepted. By submitting a response, you confirm that the response does not contain any confidential information.

 

Point of Contact
Jonathan Jakischa
Area of Interest
  • Commercial & Industrial Design
  • Medical Products & Services
  • Medical Equipment & Supplies
  • Other
  • Pharmaceuticals
  • Pharmaceutical R & D
Organization
Thermo Fisher Scientific
Due Date
March 30, 2018
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