Pfizer seeks to collaborate with organizations that have monoclonal antibodies (mAb) suitable for antibody drug conjugation (ADC). Pfizer has two decades of experience in developing therapies based on antibody drug conjugation and have developed an extensive set of proprietary linkers and payloads that can be leveraged for this collaboration.
Pfizer would like to conjugate their linkers and payloads to your mAb and provide you with ADC materials to test in your in vitro and in vivo models.
Key Success Criteria:
To be considered for the ADC approach, monoclonal antibodies will demonstrate the following capabilities:
Approaches Not of Interest:
Pfizer is not currently interested in assessing mAbs that do not target cancer cells or in assessing mAbs that cannot be generated in sufficient quantity to enable conjugation.
Preferred Collaboration Type:
Pfizer seeks to evaluate your mAb for potential utility as an ADC under a material evaluation agreement.
Pfizer will conjugate their linkers and payloads to your mAb and provide you with ADC materials to test in your in vitro and in vivo models. As no single linker/payload combination will work for all ADC targets, access to Pfizer's extensive set of next generation linkers and payloads will improve the chance that your mAb will succeed as an ADC.
Strong signs of efficacy and safety may lead to a further research collaboration with the aim of rapidly progressing towards entry into clinical studies.
The partner organization must hold full rights to license (or sublicense) the mAb that are tested.
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