Pfizer seeks to partner with leading academic groups and biotechnology companies in Asia to expand their current understanding of the molecular and mechanistic nature of the association and causality between brain inflammation and neurological disease pathogenesis. Pfizer's interests include the development of therapeutics, imaging agents and biomarkers for neuroinflammation.
Inflammation plays a substantial role in the morbidity and mortality of acute and chronic neurological insults and disorders. Heightened brain inflammation puts patients at a significant risk for exacerbation of degenerative and psychiatric symptoms. Microgliosis and astrocytosis secondary to these inflammatory processes are a major factor in the disability seen in the short and long term sequelae of neuroinflammatory conditions.
Despite an abundance of preclinical data supporting possible involvement of neuroinflammation in neurological disease pathogenesis, little is understood about the molecular and mechanistic nature of the association and causality that exists between brain inflammation and disease pathogenesis. Moreover, although numerous preclinical observations suggest a therapeutic potential for lowering brain inflammation, anti-inflammatory drugs have shown little success in clinical trials.
Key Success Criteria:
Successful responses will:
Approaches Not of Interest:
Animal or in-vitro work leading to an initial hypothesis that has no robust measurable clinical data supporting the rationale
Preferred Collaboration Type:
As the world’s leading biopharmaceutical company, Pfizer is proud to offer our Asian partners access to our world-class research scientists, our cutting-edge capabilities in medicine and vaccine design, our global network of external collaborations, and our industry-leading manufacturing and commercial capabilities. We are confident that you will find Pfizer to be a great partner in advancing your science and bringing high-impact medicines and vaccines to improve human health. We will explore partnering models that most suit our collaborative opportunity.
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