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A partner to design & build, or supply, a solution to high-flow continuous in-line particle filtration, concentration and collection

Request Number N684484
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Description

GSK are seeking a partner to design & build, or supply, a continuous particle collection module that can operate comfortably at >80Lh-1.  The requirement is to provide a system that can collect a suspension of particles (ranging between 8-120µm in diameter), retain the particles and filter through a majority of the carrier fluid, leaving behind an increased concentration of particle suspension in fluid.  

 

 

Figure 1. Conceptual schematic of the requirement

 

A buffer switch procedure to displace the carrier fluid (as a step to wash the particles) is also essential, and therefore the system will need to accommodate this. The system will need to be solvent resistant (aqueous, oil and alcohols) and the process should be a suitable continuous filtration/removal method. Following washing the particles will be collected as a concentrated slurry.

 

Background

GSK are looking to improve their manufacturing portfolio, and the requirement for a filtered collection device will significantly enhance the capability of collecting particles at significant flow rates.

 

The Manufacturing Technology Roadmap (MTR) within GlaxoSmithKline (GSK) has been tasked with delivering quality, affordable products to patients by reducing the complexity of the manufacturing process. 

 

A solution to this problem could be implemented in multiple manufacturing streams within GSK.

 

Key Success Criteria
  • Non-agglomerated particle suspension during the concentration process and the removal of the concentrated slurry
  • Must ensure that particles are retained & concentrated, and are not removed alongside the majority of the carrier fluid. It is also essential that the particles are kept in flow (the method of keeping the particles in flow needs to be gentle enough to prevent breaking the particles), and that they are not allowed to settle or agglomerate
  • Operate at >80Lh-1, initially with continuous operation for several hours with ideal development into continuous operation over 24h
  • Can operate at a minimum of 100g h-1 of particles with the view to operate at 10kg h-1
  • Flowing carrier fluid through removal
  • Solvent resistance
  • Washing stages incorporated into the continuous line is also important
  • Advantageous but not essential:
    • Input pipe diameter - currently 1/4” OD tubing, flexibility in the piping size can be accommodated for
    • Thermal and pressure control of the system would be advantageous

 

 

Possible Approaches
  • A continuous filtration method, such as multi-step single-pass ultrafiltration

 

 

Approaches not of interest

Previous work/operations have found that: (i) collecting the particles dry leads to agglomeration issues; (ii) the lack of sufficient stirring also creates agglomeration issues; (iii) flow rate of the carrier fluid removal exceeds that of the input suspension. Therefore, the following approaches are not of interest:

 

  • Dry powder isolation
  • Conventional filter driers
  • Mechanical stirring – blade based approaches to keeping the particles in-flow is not of interest

 

Preferred Collaboration types
  • Joint Development
  • Contract Research
  • Contract Analysis and Testing
  • Technology Licensing
  • Consulting
Items to be submitted
  • A proposal describing the solution and how the success criteria will be met with the proposed solution
  • A non-confidential description of the technology and a schematic of the solution

 

Point of Contact
Stephen Clulow
Area of Interest
  • Food & Beverage
  • Manufacturing & Fabrication
  • Materials Processing
  • Pharmaceuticals
  • Research Organizations
  • Universities & Colleges
  • Other
Organization
GSK
Due Date
March 15, 2018
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Comments
if you allow me to study the physical aspect of the process, I can realize a continuous countercurrent washing.
I have a positive experience in creating similar non-standard equipment in the chemical and pharmaceutical industries of Ukraine and Latvia.
Posted on 2/12/18 3:05 PM.
And my technology will satisfy key criterion of success is the removal of the concentrated suspension (up to pasty state) without loss of particles together with most carrier liquids and without precipitation of the particles during the washing process!
Posted on 2/13/18 6:05 AM.