Antibodies are produced in mammalian, bacterial and yeast cells. These are grown in 1000 to 2000 litre fermenters.
It is vitally important that the fermenter and purification systems contain sterile media. Contaminants affect the fermentation process and can produce lipopolysaccharides (LPS), also known endotoxin, that can elicit strong (often adverse) immune responses in humans. Endotoxins are large molecules consisting of a lipid and a polysaccharide composed of O-antigen and are found in the outer membrane of Gram-negative bacteria. The total number of unwanted microbes in a culture media is called ‘Bioburden’.
Tests for bioburden/endotoxin are typically offline tests, that are conducted in separate laboratories in the manufacturing site and require large pieces of equipment.
We are seeking a simple, inline sensor that will detect and report bioburden and /or endotoxin levels.
• Miniature (<1 cm2 total area)
• Detects bioburden and endotoxin and sends data through a network
• Contents of detection sensors do not leach into the process fluid
GSK is open to any approach capable of achieving the criteria set forth above.
We are looking for concise, non-confidential proposals. The proposal should:
• Describe the technical approach
• Include a description of the responding organisation or team and their experience
Please use the Respond button in order to submit your proposal.
• including a concise abstract summarising your submission
• attaching your proposal
• attaching any additional documents
Please note that only non-confidential information can be accepted. By submitting a response you confirm that the response does not contain any confidential information.