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Inline detection of bioburden and endotoxin

Request Number N958304
Author GSK
Need details
Description
Seeking a technology to detect bioburden and endotoxin in a miniature sterile vessel.
Background

Antibodies are produced in mammalian, bacterial and yeast cells. These are grown in 1000 to 2000 litre fermenters.

 

It is vitally important that the fermenter and purification systems contain sterile media. Contaminants affect the fermentation process and can produce lipopolysaccharides (LPS), also known endotoxin, that can elicit strong (often adverse) immune responses in humans. Endotoxins are large molecules consisting of a lipid and a polysaccharide composed of O-antigen and are found in the outer membrane of Gram-negative bacteria. The total number of unwanted microbes in a culture media is called ‘Bioburden’.

 

Tests for bioburden/endotoxin are typically offline tests, that are conducted in separate laboratories in the manufacturing site and require large pieces of equipment.

 

We are seeking a simple, inline sensor that will detect and report bioburden and /or endotoxin levels.

 

Key Success Criteria

• Miniature (<1 cm2 total area)

• Detects bioburden and endotoxin and sends data through a network

• Contents of detection sensors do not leach into the process fluid

 

Possible Approaches

GSK is open to any approach capable of achieving the criteria set forth above.

 

 

Approaches not of interest

None.

 

 

Preferred Collaboration types
  • Joint Development
  • Contract Research
  • Supply Agreement
Items to be submitted

We are looking for concise, non-confidential proposals. The proposal should:

• Describe the technical approach

• Include a description of the responding organisation or team and their experience

 

Please use the Respond button in order to submit your proposal.

 

We recommend:

• including a concise abstract summarising your submission

• attaching your proposal

• attaching any additional documents

 

Please note that only non-confidential information can be accepted. By submitting a response you confirm that the response does not contain any confidential information.

 

Point of Contact
Stephen Clulow
Area of Interest
  • Aerospace & Defense
  • Chemical Manufacturing
  • Commercial & Industrial Design
  • Family & Consumer Products & Services
  • Food & Beverage
  • Manufacturing & Fabrication
  • Materials Processing
  • Medical Products & Services
  • Pharmaceuticals
  • Research Organizations
  • Universities & Colleges
Organization
GSK
Due Date
April 21, 2017
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