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Request for Proposal
Status: RFP is Closed

Nicotine Sequestering

Request Number
RFP_2019_0115
Due Date
Jul 8
Program Manager

Opportunity

Licensing, Product Acquisition, Contract Research, Proof of Concept leading to scale-up to manufacturing, Joint Development, Supplier Agreement, etc.

Timeline

Phase 1: Identify available technology and verification or development of selected technology – up to 6 months

Phase 2: Technology verification in pilot scale or scale up possibility assessment – 6 to 12 months

Financials

All financials to be determined jointly with the client.

SOLUTION PROVIDER HELP DESK USA:
 
RFP was closed on
Jul 2019

RFP Title

 

Nicotine Sequestering
RFP Description

NineSigma, representing a global tobacco company, invites proposals for technologies to enable degrading or sequestering of nicotine in the production of very low nicotine tobacco while maintaining its sensorial attributes.

Background

Nicotine is a substance that occurs naturally in tobacco leaves. The possibility exists that future governmental regulations will require a significant reduction in the concentration of nicotine in combustible tobacco products. One possible method to reduce nicotine content is through extraction where tobacco solubles are filtered through a material which selectively removes only the nicotine.  Preferably this technology should not negatively affect the flavor profile of the end product, have undesirable side reactions, or cause disruptions in the process, such as to pH or temperature requirements, which would make implementation a challenge. NineSigma’s client desires a cost-effective technology to significantly lower levels of nicotine in tobacco by 98% or greater relative to those found naturally in tobacco.

 

Anticipated Project Phases or Project Plan

Phase 1: Identify available technology and verification or development of selected technology – up to 6 months 

Phase 2: Technology verification in pilot scale or scale up possibility assessment – 6 to 12 months

 

Criteria for Moving from Phase 1 to Phase 2

Client will consider for advancement an approach that meets performance criteria with acceptable economics and pathway to commercialization.

Key Success Criteria

The successful technology will:

  • Reduce nicotine in tobacco by >98%
  • Retain the sensorial and flavor characteristics of the tobacco
  • Be scalable to an industrial level
  • Be cost-effective

 

Solutions that provide a novel application methodology while meeting the other requirements are also of interest.

Possible Approaches

Possible approaches might include, but are not limited to:

  • Antibodies, peptides, or other molecules that will selectively adhere to nicotine
  • Technologies adapted from other industries, such as:
    • Biofuels
    • Water/wastewater treatment
    • Wine preservation
    • Decaffeination
Approaches not of Interest

The following approaches are not of interest:

  • Approaches that affect the sensorial attributes, especially the flavor profile, of the tobacco
Items to be Submitted

Your response should address the following:

  • Non-confidential description of proposed technology and working principle
  • Percent reduction in nicotine concentration or ppm achieved by the technology
  • Effect of the sequestering process on sensorial characteristics and flavor compounds of the tobacco
  • Technical maturity of the approach (concept, reduced to practice, prototype, ready to commercialize, ready to implement, commercialized)
    • Pathway to industrial scale including timing, estimated budget, and capacity for manufacture
  • Estimated unit cost of the technology
  • Position on intellectual property including patent references
  • Desired relationship with sponsor
  • Team description and related experience

 

Responses from companies (small to large), academic researchers, other research institutes, consultants, venture capitalists, entrepreneurs, or inventors are welcome.

Preferred Collaboration Types
Area of Interest