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Request for Proposal
Status: RFP is Open

Minimally Invasive Measurement of Mitochondrial Function

Request Number
RFP_2019_0125
Due Date
Aug 4
Program Manager

Opportunity
Joint research, joint development, product supply

 

Timeline
Partner selection: Within 6 months
Start of collaboration: Within 1 year

 

Financials
Required budget guaranteed
(negotiable depending on the proposal)

 

How to  Apply

  • Click "Respond", complete the form to the extent possible, and submit along with other attachment files available. 
  • After creating your account for NineSights, your draft will be automatically saved and you can resume later from "Control Center". Please note you do not submit confidential information at this process.
  • This request for proposals in PDF format is available here.
SOLUTION PROVIDER HELP DESK
If you have any questions or request, please feel free to contact us at: phd2@ninesigma.com 

RFP Title

 

Minimally  Invasive Measurement of Mitochondrial Function
RFP Description

NineSigma, representing Suntory Global Innovation Center Limited, seeks proposals concerning the development of technologies to measure human mitochondrial function in a minimally invasive manner. In particular, our client focuses on the functions involved in the production of ATP by oxidative phosphorylation. Proposals from a wide range of fields such as life sciences, engineering, pharmaceutics, and medicine are welcome.

Key Success Criteria

KEY SUCCESS CRITERIA
It is desirable to meet all the following requirements (“Essential” and “Conditions welcomed”); however, at this stage, proposals for the development of technologies that are expected to meet the “Essential Requirements” below are welcome.

Essential Requirements

  • The items that are correlated with mitochondrial function shall be able to be evaluated quantitatively.
  • The method of measurement shall be non-invasive or less invasive such as:
    • Minimally invasive measuring and sampling for urine, sweat, exhalation, body odor, blood, etc.
    • Measurement shall be possible using a wearable device that does not require sampling.
  • It shall be potentially possible to carry out measurement in humans.

Conditions welcomed (not mandatory)

  • Past measurement achievements in vivo
  • High throughput
  • No need for large-scale equipment
Possible Approaches

Possible Measurement Items

Possible measurement items might include, but are not limited to:

  • Oxygen consumption
  • Substrate consumption rate of mitochondrial enzymes
  • Oxygen partial pressure in mitochondria
  • Amount of glutathione, redox status
  • Amount of reactive oxygen species (ROS)
  • Mitochondrial membrane potential
Approaches not of Interest

Measurement Items Not of Interest

The following measurements are not of interest:

  • Mitochondrial function that is less related to ATP production by oxidative phosphorylation
    • Synthesis of steroid and heme
    • Regulation of the intracellular concentration of calcium and iron
    • Regulation of cell cycle and apoptosis, etc.
Items to be Submitted

Background

Our client aims to support the maintenance and improvement of human physical functions through the development of novel functional foods and beverages. This request focuses on mitochondrial function among human physical functions and seeks a technology that can easily measure human mitochondrial function.

Although a biopsy of the target tissue is commonly required to measure human mitochondrial function, the significant burden on the test subject that is caused by this is a problem to be solved.

Therefore, our client decided to issue this request to companies and researchers all over the world so as to find a joint partner that is willing to develop a technology that measures human mitochondrial function in a minimally invasive manner.

 

Notes on Response

Proposal shall have clear points and should not include confidential information. Supplemental files may be submitted in addition to the proposal.

 

Response evaluation

The client will evaluate all responses with the following criteria.

  • Overall scientific and technical merit
  • Approach to proof of concept or performance
  • Economic potential of concept
  • Realism of the proposed plan (action items, timeline, roles, deliverables, cost estimation)
  • Potential for proprietary position
  • Respondents’ capability and related experiences

 

Anticipated Project Process

After reviewing submitted proposals, the client possibly ask clarifying questions before selecting the most suitable candidates for collaboration. The client will select best candidates through evaluations. During the selection process, the client may execute NDA with selected respondents, seek further information disclosure, and discuss specific development targets or potential opportunities.

The client will execute necessary agreements with the selected respondents and move to the advanced development phase. Specifics of any collaboration will be determined through consultation with the concerned parties.

Preferred Collaboration Types
Area of Interest