Aging, refractory muscle-related diseases, etc. cause morphological changes and dysfunction in skeletal muscle. Musculoskeletal dysfunction leads directly to motor functional decline, which reduces activities of daily living (ADL) and quality of life (QOL). Recent global trends in population aging indicate the number of patients suffering from muscular diseases, such as sarcopenia, will increase, and the establishment of efficient cure to attenuate skeletal muscle dysfunction is an urgent task.
In the area of muscle-related diseases, new drug discovery targets have been being discovered with the progress of science in recent years such as myostatin and mitochondria, which is responsible for energy metabolism. On the other hand, high unmet medical needs are still existing in that area.
The Client aims to develop innovative drugs to cure muscle-related diseases to meet these unmet medical needs. They decided to seek potential partners this time to accelerate R&D through collaborations with organizations with cutting edge technologies in the area of muscular diseases.
Anticipated Project Process
After the submission due date, the client will review all submitted proposals. NineSigma will send the review results to each proposer 6-8 weeks after the due date. The client possibly asks clarifying questions before selecting the most suitable candidates for collaboration. The client will select best candidates through evaluations. During the selection process, the client may execute NDA with selected respondents, seek further information disclosure, and discuss specific development targets or potential opportunities.
The client will execute necessary agreements with the selected respondents and move to the advanced development phase. Specifics of any collaboration will be determined through consultation with the concerned parties.
Proposal shall have clear points and should not include confidential information. Supplemental files may be submitted in addition to the proposal.
The client will evaluate all responses with the following criteria.
- Overall scientific and technical merit
- Approach to proof of concept or performance
- Economic potential of concept
- Realism of the proposed plan (action items, timeline, roles, deliverables, cost estimation)
- Potential for proprietary position
- Respondents’ capability and related experiences