Non-invasive Indicators for Easy Detection and Monitoring of Cognitive Decline

Request Number REQ4370572
Due Date April 6, 2018
Request for Proposal Details
RFP Title
Non-invasive Indicators for Easy Detection and Monitoring of Cognitive Decline
RFP Description

NineSigma, representing a multibillion-dollar major manufacturer, seeks non-invasive, detectable indicators that reflect a decline in cognitive function, to ultimately apply the technology as a device or application that enables daily monitoring of cognitive function. Organizations that have successfully developed a device or application enabling monitoring of cognitive function will be considered as a business partner for collaboration.



Dementia, a condition that develops in one in seven people aged 65 or older, has become a serious social issue. It is expected that the rapidly aging society will further increase the number of dementia patients. While drugs to suppress progression of dementia have been discovered, those to radically cure this disease have yet to be developed. Thus, early diagnosis and prevention play a pivotal role.


Although early diagnosis technologies using imaging techniques have been developed, examination can be performed only at a medical institution. Signs of a decline in cognitive function may be overlooked.


Meanwhile, some reports shows a relationship of non-invasive, detectable indicators, such as behaviors and physiological function observed in daily life, with cognitive function.


The client wishes to establish a technology that contributes to early diagnosis and prevention by providing a device or application that more easily enables monitoring of cognitive function. Therefore, the client has issued this open request to accelerate development in collaboration with a potential partner that has developed non-invasive, detectable indicators.


Key Success Criteria

Requirements of the proposed technology

  • The sought indicators should fulfill the following requirements:
    • There should be reasonable grounds for the correlation with cognitive function.
    • The indicators should be easy, non-invasive, detectable ones that can be seen in daily life.
    • Easy to use or monitor by utilizing a wearable/portable device, mobile application or non-invasive sensors
  • Medical practice, such as blood collection, should not be involved.


Possible Approaches

Anticipated Indicators

Anticipated indicators include, but are not limited to, the following:

  • Behavioral patterns (walking speed, steps, activity range, etc.)
  • Sleep patterns (sleep duration, somniloquence loudness, etc)
  • Excretion patterns
  • Dietary patterns (intake, food balance, etc.)
  • Voice, dialogue, speaking smoothness
  • Heart rate
  • Facial expressions
  • Emotional dysregulation
  • Calculation ability
  • Eye movements
  • Sweat rate
  • Water intake
  • Blood oxygenation level and blood pressure fluctuation
  • Audibility and eyesight
  • Oral function (Components in saliva, etc)


Anticipated Project Phases or Project Plan

Respondents should submit proposals using the attached Response Template.

The client will review submitted proposals and possibly ask clarifying questions before selecting the most suitable candidates for collaboration. The client will select the best candidate(s) through evaluations. During the selection process, the client may execute non-disclosure agreements (NDA) with selected respondent(s), seek further information disclosure, and discuss specific development targets or potential opportunities.

The client will execute necessary agreement(s) with the selected respondent(s) and move to the advanced development phase. Specifics of any collaboration will be determined through consultation with the concerned parties.


Preferred Collaboration types
  • Joint Development
  • Contract Research
  • Technology Licensing
Items to be submitted

Items to be Submitted

Responses will use the Proposal Template and include the following items:


  • Overview of the technology
    (principle, characteristics)
  • Development stage
    (Concept level, demonstration level, practical-use level)
  • Current performance
    • Indicators
    • Rationale and supporting data for the relationship between the above indicators and cognitive function
    • Measurement platform or approach anticipated when the technology is applied to a device or application (How to measure with what type of devices, etc)
  • Current challenges and development plans to ultimately fulfill the requirements
  • Past achievements (e.g. additional information supporting the R&D capabilities, such as research papers and patents)
    • Intellectual properties related to the proposal are of particular interest, such as patent and registered design.
  • Corporate overview


Area of Interest
Request Priority