RESPONSE DUE DATE: March 14, 2018
MANAGER: K. Ogata
SOLUTION PROVIDER HELP DESK EMAIL: PhD2@ninesigma.com
‐ Technical support in developing the proposed in vitro assay system into high-throughput screening
‐ Results obtained from High-throughput screening (HTS) analysis by Astellas will be informed to respondents within a releasable range. Respondents can make use of the results for research activities freely, and basically, can publish them with prior notice.
‐ Depending on HTS results, the client may propose another collaboration opportunity, and upon request, provide hit compounds in HTS according to conditions.
‐ Academic publications (e.g. Chemical Biology) are basically acceptable with prior consultation in case that promising candidates are discovered.
Up to 1 year (depending on the optimization level of the system)
NineSigma, representing Astellas Pharma Inc. (https://www.astellas.com/en/), seeks a novel in vitro Disease-relevant assay system (e.g. phenotype assay etc.). Astellas aims at developing the proposed assay system into high-throughput screening system and using for screening of their compound library. They are eager to collaborate with potential partners willing to work on this project.
The client has been engaged in the R&D of new drugs to address unmet medical needs. As a part of this challenge, they actively conducts R&D not only for developing new compounds, but also for exploring new indications of marketed drugs or in-house compounds for which R&D was discontinued. In these efforts, to improve the efficiency of drug discovery and launch drugs earlier, it is crucial to establish an in vitro assay system with high extrapolation that reflects a Disease-relevant condition in humans. Furthermore, high-throughput technology is required for efficient drug discovery. They aims at achieving this point combining promising assay system possessed partners with Astellas’s proprietary advanced platform technologies
Therefore, the client has issued this open request to seek a wide range of potential organizations that have already developed highly unique in vitro assay system.
Requirements of the in vitro assay system
The client seeks an in vitro assay system that fulfills the following requirements:
Anticipated Project Phases or Project Plan
Respondents should submit proposals using the attached Response Template.
Proposals will be evaluated primarily and then successful providers can obtain the opportunity of direct discussion with the client. The client may execute non-disclosure agreements (NDA) with selected respondents and seek further information disclosure to select the best candidates. If the client discovers a potential proposal, they will conclude a technical guidance agreement with the potential partner, and if necessary, a license agreement. (If effective compounds are found as a result of screening at Astellas, the client may conclude a joint research agreement with the potential partner, separately.)
Responses will use the Proposal Template which is linked to the “attachments” shown at the bottom this page and include the following items: