Development Partner for POC Testing Device of Blood Protein

Request Number REQ9366150
Due Date March 16, 2018
Request for Proposal Details
RFP Title
Development Partner for POC Testing Device of Blood Protein
RFP Description

NineSigma, representing a multibillion-dollar major medical device manufacturer, seeks development partners for point-of-care (POC) testing device of a tiny amount of blood protein. Of particular interest is high-sensitive detection technology capable to accomplish the testing with short processing time even for low-volume blood sample.



A major medical device manufacturer, a client of NineSigma, has been working on development of detection devices for a small amount of blood biomolecules at high speed. The client is eager to apply the devices to the point-of-care (POC) testing that is expected to expand in the health-care field near future. POC refers to a system whereby sample testing is completed in a short time regardless of location (e.g., bedside of patients), which enables medical staffs to rapidly detect patient’s abnormality and immediately make an appropriate medical decision.


However, as defined, POC devices require rapid testing, simple structure and high sensitivity to a small amount of sample. The client seeks to realize a device capable of detecting blood protein, but faces with difficulties to adopt a conventional detection methods requiring B/F separation for POC applications, in terms of processing speed and convenience.


However, in recent years many companies and research institutes have a similar direction to the client and are engaged in developing devices applicable to the POC field. The client has thus decided to make this open request for proposals to accelerate the device development by leveraging partnership with promising organizations.


Key Success Criteria

Target to be detected

  • Small amount of protein and/or peptide molecules in blood (e.g. hormones, antigens, etc.)


Detection technology ultimately to be achieved

System capable of detecting the above target at high speed. Specific requirements are as follows.

  • Sample volume: Approx. 10 μL of blood. Whole blood assay without any preprocessing such as centrifugation is particularly desirable.
  • Lower limit of detection: Approx. 10 pM in blood concentration of target
  • Processing time: Approx. within 5 minutes
  • Size at a system level: Desktop size


We anticipate brief and high-speed detection processes, such as those with an automatic B/F (Bound/Free) separation or without any B/F separation. The requirements above are extremely hard to satisfy and therefore it is not necessary to meet all at this moment. We welcome a wide range of technology proposals with an early-phase approach as long as they have a potential feasibility to achieve the requirements through an additional development of about 5 years.


Anticipated project phases or project plan

Respondents should submit proposals using the attached Response Template.


The client will review submitted proposals and possibly ask clarifying questions before selecting the most suitable candidates for collaboration. The client will select the best candidate(s) through evaluations. During the selection process, the client may execute non-disclosure agreements (NDA) with selected respondent(s), seek further information disclosure, and discuss specific development targets or potential opportunities.

The client will execute necessary agreement(s) with the selected respondent(s) and move to the advanced development phase. Specifics of any collaboration will be determined through consultation with the concerned parties.


Possible Approaches

Possible approaches

Possible approaches include, but are not limited to:

  • Processing technology capable of detecting a small amount/low concentration of biomolecules
    • High-speed detection with a small-amount sample through automatic B/F separation
    • Brief detection method without B/F separation


Preferred Collaboration types
  • Joint Development
  • Contract Research
  • Technology Licensing
  • Supply Agreement
Items to be submitted

Items to be submitted

Responses will use the Proposal Template and include the following items:


  • Overview of the technology/measurement process
  • Uniqueness of the technology/measurement process
  • Development stage (concept level / technology testing level / already implemented to devices)
  • Current performance
    • Detectable blood substances
    • Minimum amount of blood sample required for detection
    • Lower limit of detection
    • Processing time
    • Expected size as a device
  • Challenges to meet the final requirements, and future development plans


Area of Interest
Request Priority