requests-for-proposal

Bioabsorbable Substance with Tissue Adhesive Effect

Request Number REQ5362982
Due Date February 8, 2018
Request for Proposal Details
RFP Title
Bioabsorbable Substance with Tissue Adhesive Effect
RFP Description

NineSigma, representing a major pharmaceutical company, seeks a bioabsorbable substance with a tissue adhesive effect on organs, etc.

Background

By combining the substance sought in this request with the client’s proprietary commercialization technology and development know-how, the client intends to develop and commercialize a tissue adhesive sealant to fulfill an unmet need in surgical procedures in clinical practice. Currently, fibrin glue is commonly used as a tissue adhesive sealant in a surgical field. In this request, compounds with a tissue adhesive effect, other than fibrin glue, are widely sought, regardless of whether they are bio-derived, naturally derived, or synthesized ingredients.

 

Development plan

Development is currently planned according to the following schedule:

  • The client will conduct product design and a clinical trial will start in 2 to 3 years.
  • The adhesive will be launched in 4 to 5 years.

 

Key Success Criteria

Requirements of the Candidate Substance

The requirements of the candidate substance are as follows:

  • Anticipated application: Tissue adhesive sealant for implantation during surgery
  • Should have a tissue adhesive effect
    • An effect equivalent to or greater than that of commonly used fibrin glue is expected.
    • Perferably, an effect of sealing is expected.
  • Should be bioabsorbable
  • Development level:
    • The substance has already been optimized.
    • The efficacy has been confirmed in an in vitro or in vivo study.
  • With regard to safety, it is likely that the substance will be applicable to humans as an implanted product.
    • It is preferable that the safety has already been assessed.

 

Approaches not of interest

The following compounds are not of interest:

  • Plasma-derived fibrinogen and human genetically modified fibrinogen

Anticipated Project Phases or Project Plan

Respondents should submit proposals using the attached Response Template.

The client will review submitted proposals and possibly ask clarifying questions before selecting the most suitable candidates for collaboration. The client will select the best candidate(s) through evaluations. During the selection process, the client may execute non-disclosure agreements (NDA) with selected respondent(s), seek further information disclosure, and discuss specific development targets or potential opportunities.

The client will execute necessary agreement(s) with the selected respondent(s) and move to the advanced development phase. Specifics of any collaboration will be determined through consultation with the concerned parties.

 

Preferred Collaboration types
  • Joint Development
  • Technology Licensing
Items to be submitted

Responses will use the Proposal Template which is linked to the “attachments” shown at the bottom of the link <REQ5362982> and include the following items:

 

  • Overview of the proposed substance (anticipated application, mechanism of action, etc.)
  • Properties of the proposed substance (state and processability of the substance [properties in a powder/liquid form, etc.], stability, sterilization resistance, etc.)
  • Assessment examples (please describe the current assessment)
    • Performance
      • Tissue adhesive effect
        • Data showing the adhesiveness/speed of adhesiveness expression/duration of adhesiveness/resistance to an external load (resistance to the movement of tissue, such as slippage, expansion and contraction, resistance to water, etc.)
      • Bioabsorbability
        • Data showing the bioabsorbability,etc.
      • Other
        • Date showing the sealing effect, etc.
    • Safety, etc.
  • Current R&D stage
  • Future R&D plan and challenges
  • Request regarding the form of collaboration
  • Joint research achievements with a third-party organization in the proposed seeds
  • Status of intellectual property of the proposed technology
  • Achievements in past research

Area of Interest
Request Priority
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