Nitrosamine Deactivation

Request Number REQ7343887
Due Date May 15, 2017
Request for Proposal Details
RFP Title
Nitrosamine Deactivation
RFP Description

NineSigma, representing a global consumer product company, invites proposals for technologies capable of deactivating naturally-occurring nitrosamines during processing and storage.


Nitrosamines are compounds that are produced naturally by a variety of products, including plants, processed meats and other products. These compounds have the potential for serious negative health impacts.


Nitrosamine formation can occur on the surface as well as internally inside cells. Additionally, the levels of these compounds can increase during storage or during the production cycle.


NineSigma’s client processes nearly 800 million pounds of base material annually into a consumable product. Consequently, a mechanism, such as photo-deactivation of the nitrosamine compounds, to treat the material is highly desirable. Treatment may occur after the initial processing stage, prior to storage or both.


Conceptual technologies, as well as more established approaches, are of interest for this request.


Anticipated Project Phases or Project Plan

Phase 1 – Proof of concept

  • Lab scale proof of nitrosamine deactivation


Phase 2 – Commercial development

  • Industrial evaluation of nitrosamine deactivation technology


Criteria for Moving from Phase 1 to Phase 2

Client will consider for advancement an approach that meets performance criteria with acceptable economics and pathway to commercialization.


Key Success Criteria

The successful technology will:

  • Deactivate the nitrosamine compounds OR
  • Reduce the amount of nitrosamine present within the base material
  • Deactivate the microorganisms that mediate nitrosamine formation


Possible Approaches

NineSigma’s client is open to all approaches with the ability to reduce or eliminate the production of nitrosamines.


Approaches not of interest

Any technology which negatively impacts the integrity of the base materials.


Preferred Collaboration types
Items to be submitted

To respond, please make sure you are registered in NineSights, as it will prompt you to log in. Then, use the Response options at the top or bottom of the page. You may submit supplemental files in addition to your completed response form.


Appropriate responses will use the response form and address the following:

  • Non-confidential description of proposed technology and working principle
  • Availability of technical data
  • Technical maturity of the approach (concept, reduced to practice, prototype, ready to commercialize, ready to implement, commercialized)
  • Pathway to commercial scale including timing, estimated budget, and capacity for manufacture
  • Estimated unit cost of technology
  • Position on intellectual property including patent references
  • Desired relationship with sponsor
  • Team description and related experience


Other Request information includes:



Responses from companies (small to large), academic researchers, other research institutes, consultants, venture capitalists, entrepreneurs, or inventors are welcome. For example:


You represent a company or university that has demonstrated a proof of concept.

You represent a company or university that has reduced method to practice at lab scale.

You represent a company or university that has developed a method for use at pilot scale.

You represent a company or university that has demonstrated a method ready for implementation at industrial scale.

You represent a university research department that has a bench-scale demonstration ready to adapt.

You represent a university research department that has an undeveloped pathway with a high probability of success.



Area of Interest
Request Priority
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