Experts in Interactions of Active Ingredients with Skin

Request Number REQ2287854
Due Date June 19, 2015
Author Nick Kacsandi
Request for Proposal Details
RFP Title
Experts in Interactions of Active Ingredients with Skin
RFP Description

NineSigma, on behalf of a Global Specialty Products Manufacturer, is seeking Subject Matter Experts with a deep understanding of the biological and/or chemical mechanisms by which human skin interacts with topical analgesics such as menthol. Experts from across the landscape of industry, consulting and academia are invited to respond by filling out the short Expert Capabilities Form linked in the “Items to be Submitted” section below.


NineSigma’s client has established a robust knowledge base around the superficial effects of topical treatments on pain. The client is looking for an expert who can define and consult regarding the mechanisms by which topical ingredients create pain relief and identify related pharmacokinetics associated with the duration and efficacy of the active ingredients. The purpose of this Expert Request is to identify elite partners who can help establish a more robust understanding of the variables and relationships between the physiological and biochemical pathways involved in these reactions.


As such, Experts are sought to act as consultants, research partners or technical solution providers in this area. Specifically, top respondents may be invited to engage with the client in a variety of opportunities, including – but not limited to:

  • Educate the client on effects and interactions of topical treatments on human skin
  • Recommend appropriate strategies, tools and/or partners for research and development
  • Evaluate technologies to extend the duration of topical pain relief and consult on their mechanisms and likelihood of success.
  • Conduct appropriate research or analysis in conjunction with client’s technical team, as needed



Key Success Criteria

The client is interested in an Expert to evaluate and prioritize technologies that provide extended topical pain relief based on their unique knowledge of skin function and the pharmacokinetics of topical agents.  Experts with a strong background in one or more of the following topics are of significant interest:

  • Impacts of internal elements such as:
    • Cellular interactions and cell receptor activity
    • Saturation points of active ingredients, such as menthol
    • Release and stimulus/adaptation kinetics
    • Absorption efficiency
    • Neurophysiological responses
    • Pharmacokinetics
  • Impacts of external elements such as:
    • Dosage of the active
    • Duration of exposure
    • Tolerance and adaptation
    • Variations in response amongst individual populations (age, gender, ethnicity, etc.)


Potential experts may be involved in a wide range of technical disciplines, including – but not limited to:

  • Topical Pharmacokinetics
  • Skin Science
  • Dermatology
  • Drug Delivery
  • Applied Biology
  • Biochemistry
  • Pharmacology
  • Healthcare & Medicine
  • Microbiology
  • Therapeutics
  • Immunology


Preferred Collaboration types
Items to be submitted

To respond to this Expert opportunity, please follow the link below to access and complete our Expert Capabilities Form. The link will transfer you to a short, online form where you will have the opportunity to highlight your expertise related to this technical need area. Note that in addition to this form you will also have the option to upload up to three (3) documents in support of your responses.





Area of Interest
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