requests-for-proposal

Technology to Deposit Hydrophilic Polymer to Surface of Hydrogel

Request Number REQ3365328
Due Date May 4, 2018
Request for Proposal Details
RFP Title
Technology to Deposit Hydrophilic Polymer to Surface of Hydrogel
RFP Description

NineSigma, representing a Global Leader in medical devices and specializing in hydrogel materials, invites proposals for technologies that can deposit hydrophilic polymer to hydrogel surface to achieve a slow-release delivery of the polymer under controlled conditions.

Background

It is desired to release a hydrophilic polymer (water soluble) from the surface of the medical device (hydrogel).

 

The RFP sponsor is seeking innovations that can continuously release a hydrophilic polymer from the surface of the hydrogel in vivo for at least 8 hours and up to 24 hours.

 

Key Success Criteria

The desired technology must:

  • Deposit small amounts (~ 1-micron thick layer, or up to 50mg/cm2) of a hydrophilic polymer (viz. anionic polysaccharides, glycosaminoglycans) of MW greater than 1 million Da on the surface of a hydrogel material.
  • Release the hydrophilic polymer from the hydrogel in vivo using an appropriate trigger (i.e. mechanical stress, light, enzymatic, ionic strength etc.), ideally with zero order kinetics.
  • Be transparent (have high light transmissibility).
  • Be biocompatible.

Preferred features

  • Be capable of withstanding high temperature processing, including autoclaving: a significant amount of the hydrophilic polymer should be retained on the surface. (NOTE: this specification is based on the currently established method for processing medical device materials. Innovations that do not require autoclaving for sterilization will be considered for this RFP).
  • Coating would not have a burst release, and would not rub off with gentle handling or during extended storage in aqueous media at neutral pH and room temperature.
  • Hydrogel surface should be smooth after deposition, with roughness features at most ~ 1-micron.

 

Possible Approaches

Possible approaches might include, but are not limited to:

  • Microfabrication techniques for printing or depositing polymer on hydrogel surface.
  • Self-assembly of polymer from solution (phase separation, sol-gel transition, etc.).
  • Inter-penetrating network of hydrophilic polymer with hydrogel.
  • Reversible attachment of hydrophilic polymer to functionalized hydrogel surface.

 

Approaches not of interest

The following approaches are not of interest:

  • Burst release or non-releasable coating (a coating that is permanently bonded to the hydrogel surface)
  • Non-robust coatings that are removed by gentle handling.
  • Bulk release from inside the lens (unless there is already proof of concept for this approach).

 

Preferred Collaboration types
  • Joint Development
  • Contract Research
  • Contract Analysis and Testing
  • Technology Licensing
  • Technology Acquisition
  • Supply Agreement
  • To Be Negotiated
Items to be submitted

Your response should address the following:

  • Non-confidential description of proposed technology and working principle
  • Availability of technical data
  • Technical maturity of the approach (concept, reduced to practice, prototype, ready to commercialize, ready to implement, commercialized)
  • Pathway to commercial scale including timing, estimated budget, and capacity for manufacture
  • Position on intellectual property including patent references
  • Desired relationship with sponsor
  • Team description and related experience

 

Appropriate responses to this Request

Responses from companies (small to large), consultants, entrepreneurs, or inventors are welcome.  For example:

 

You represent a company or university that has demonstrated a proof of concept.

You represent a company or university that has reduced method to practice at lab scale.

You represent a company or university that has developed a method for use at pilot scale.

You represent a company or university that has demonstrated a method ready for implementation at industrial scale.

You represent a technology transfer agency that represents an inventor or technology holder who can demonstrate an approach to address the request.

You represent a university research department that has a bench-scale demonstration ready to adapt.

You represent a university research department that has an undeveloped pathway with a high probability of success.

 

Area of Interest
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