PROGRAM MANAGER: Oliver Worsfold
OPPORTUNITY: Licensing, product acquisition, proof of concept leading to scale-up to manufacturing, joint development, supplier agreement
Phase 1 – Proof of concept / Principle definition and testing – 9 -12 months
Phase 2 – Scale up to commercialisation – 18-36 months
All terms to be negotiated depending on technology status
SOLUTION PROVIDER FURTHER INFORMATION
To respond to this challenge, please complete the following survey LINK
NineSigma, representing a global pharmaceutical manufacturer invites proposals for processes, manufacturing techniques, methodologies or other advances in microbiology to enable enveloped virus concentration.
Viral antigens are typically manufactured in bio-fermentation reactors from large volumes (up to 1000L) containing high concentrations of mammalian cells. During the processing and isolation of the virus, significant cell detritus (RNA, DNA, proteins etc) are produced in the supernatant, which ideally needs to be removed and the broth concentrated to enable cost effective viral loads to be produced.
In the current challenge, Ninesigma's client is producing a virus with a global neutral charge which is problematic to filter using ion exchange chromatographic techniques. Standard proven success technologies such as chromatographic columns or tangential flow filtration can’t be used because of the inherent cost. The client is looking for an alternative method / technique or process to concentrate the virus particles which does not require expensive CAPEX.
The virus of interest has a core diameter of 20-30nm surrounded by a lipid containing envelope of 45-60nm. This outer layer yields a net neutral charge.
The client is open to all ideas and especially keen to learn more from food and drink industry, agriculture or other microbiology industries. Additionally, novel fluidic devices which require development are also welcomed.
Anticipated Project Phases or Project Plan
Phase 1 – Proposal review
Review of technology and other project experience / applications.
Phase 2 – Proof of concept testing
Identification of costs required to develop proposed technology for specific application.
Criteria for Moving from Phase 1 to Phase 2
Successful demonstration of technology and proof of previous experience.
The successful technology / process will meet the following criteria:
Possible approaches might include, but are not limited to:
The following approaches are not of interest:
For assistance, please contact the Programme Manager (email@example.com).
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