Project to modify an existing commercial product, technology licensing, material supply
Phase 1: Technology evaluation with client's existing product
Phase 2: Joint project to develop a commercial drug product with time delay functionality
(This is anticipated to be a five year duration project)
To be negotiated
Please use the above email address for any questions relating to this RFP
NineSigma, representing a major consumer healthcare company, invites proposals for a technology that can be applied to an existing drug product, so that it will allow a user to take a medication at bedtime but it will not start to have an effect until just before the user wakes. It should delay the drug release for a minimum of four hours and be suitable for use with either tablets or powder-containing capsules.
If a consumer is currently using one of our client’s products, the earliest that they can currently take a tablet or pill is first thing in the morning, as soon as they wake up. It will then take a little time for the medication to have an effect. This means that there is a time early in the morning when it is not currently possible for the user to easily obtain the benefits of the product that they are using.
In order to address this, it would be convenient if the consumer could take some of the product before they retire to bed. The therapeutic effect is then delayed for a few hours until shortly before they wake up, so that when they do wake up the product has already started to work.
The client would like to be able to introduce a “night-time” version of their current product, which would have a delayed action of least four hours, and ideally 4-6 hours. After this time delay, the product would behave as if it had just been taken by the consumer. In other words, there is an “immediate release” of the drug, rather than a controlled or “sustained release”.
The client is flexible on exactly what time delay the technology should be capable of delivering, so long as the four hour minimum is met. Of more importance is that the time delay should be reproducible, so that the consumer experience when taking the product is consistent from one night to another.
The successful technology will:
Possible approaches might include, but are not limited to:
The following approaches are not of interest:
Anticipated Project Phases or Project Plan
Our client is looking for a partner than can provide a suitable time-delay technology and then work with the client to apply the time delay technology to their product, which is already commercially available. It is anticipated that the development and approval cycle for the “night-time” version will take approximately five years to bring to market, and so they are seeking an organisation that is willing to enter into a partnership with our client for such a period of time.
Phase 1 – Time-delay technology evaluation with our client’s existing therapeutic product
Phase 2 – Development of new “night-time” therapeutic product
For this much longer phase, our client would be open to following one of two possible paths:
1. Our client supplies therapeutic product samples to the technology provider, who then develops the modified “night-time” product version
2. The technology supplier works to transfer the IP and know-how to our client and then works in an advisory capacity as our client develops the new version of the product
Items to Be Submitted:
Your response should address the following:
Appropriate responses to this Request
Responses are welcomed from both commercial organisations and research institutes.